PLOS ONE：抗精神病药或可治疗多发性硬化症

小高同志

来源：生物谷 2014-08-15 19:48

2014年8月16日讯 /生物谷BIOON/--惠灵顿维多利亚大学研究人员发现：使用常见的抗精神病剂，或许可以治疗多发性硬化症（MS）。

研究人员Anne La Flamme博士领导的新研究，显示氯氮平和利培酮有潜力成为有效治疗MS的药物。

MS是一种神经系统疾病，是由免疫细胞入侵脑部，造成炎症所引起的。它会导致视力受损和协调能力受损，并最终导致瘫痪。

虽然疾病治疗药物目前已经上市，但它们往往只对MS患者中某类亚群患者有效，所有这些药物的治疗靶标是针对传统的免疫途径。

新研究发现，氯氮平和利培酮的靶向途径非常不同与其他所有MS药物的作用途径，因而将可用于治疗目前药物无法治愈的MS。

发表在杂志PLOS ONE上的研究表明，利培酮和氯氮平可以通过减少导致本病的大脑炎症，显著改善MS。（生物谷Bioon.com）

doi:10.1016/j.cell.2011.10.017
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Treatment with the Antipsychotic Agent, Risperidone, Reduces Disease Severity in Experimental Autoimmune Encephalomyelitis

David O'Sullivan，et al.

Recent studies have demonstrated that atypical antipsychotic agents, which are known to antagonize dopamine D2 and serotonin 5-HT2a receptors, have immunomodulatory properties. Given the potential of these drugs to modulate the immune system both peripherally and within the central nervous system, we investigated the ability of the atypical anti-psychotic agent, risperidone, to modify disease in the animal model of multiple sclerosis (MS)4, experimental autoimune encephalomyelitis (EAE). We found that chronic oral administration of risperidone dose-dependently reduced the severity of disease and decreased both the size and number of spinal cord lesions. Furthermore, risperidone treatment substantially reduced antigen-specific interleukin (IL)-17a, IL-2, and IL-4 but not interferon (IFN)-γ production by splenocytes at peak disease and using an in vitro model, we show that treatment of macrophages with risperidone alters their ability to bias na?ve T cells. Another atypical antipsychotic agent, clozapine, showed a similar ability to modify macrophages in vitro and to reduce disease in the EAE model but this effect was not due to antagonism of the type 1 or type 2 dopamine receptors alone. Finally, we found that while risperidone treatment had little effect on the in vivo activation of splenic macrophages during EAE, it significantly reduced the activation of microglia and macrophages in the central nervous system. Together these studies indicate that atypical antipsychotic agents like risperidone are effective immunomodulatory agents with the potential to treat immune-mediated diseases such as MS.

泥土

好消息！感谢坛主！